doi:10.1210/jc.2013-1195. eHealthMe is studying from 74,983 Vitamin b12 users. Anaphylactic reaction after injection of vitamin B12. Here are 9 signs and symptoms of vitamin B12 deficiency. “Many people experience stomach pains, nausea and even diarrhea.” Gorham ED, Garland CF, Garland FC, Grant WB, Mohr SB, Lipkin M, Newmark HL, Giovannucci E, Wei M, Holick MF. People with vitamin B-12 deficiency may have a variety of symptoms, including fatigue, nerve problems, and trouble thinking. Urashima M, Segawa T, Okazaki M, Kurihara M, Wada Y, Ida H. Randomized Trial of Vitamin D Supplementation to Prevent Seasonal Influenza A in Schoolchildren. B12 deficiency in … it damages the myelin sheath): 99 people, 5.14%, Nausea (feeling of having an urge to vomit): 97 people, 5.03%, High Blood Cholesterol: 91 people, 4.72%, Ulcerative Colitis (inflammatory bowel disease (ibd). B complex is a supplement that contains all eight B vitamins. Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial. Yes! 2007;85(6):1586-1591. doi:10.1093/ajcn/85.6.1586, Prentice RL, Pettinger MB, Jackson RD, et al. Vitamin B12 is an essential nutrient, important in nerve and blood cell health, and most people obtain enough of it in food. Heaney, Robert P. “The Vitamin D Requirement in Health and Disease.” The Journal of Steroid Biochemistry & Molecular Biology 97 (2005):13-9. Wilkins, Consuelo H. and Yvette I. Sheline, et al. Will you have Tachycardia Foetal with Morphine Sulfate? Chest pain is found among people who take Vitamin b12, especially for people who are female, 60+ old, have been taking the drug for < 1 month. Arch Intern Med. Effectiveness and Safety of Vitamin D in Relation to Bone Health. Public Health Nutr. Use of this site constitutes acceptance of eHealthMe.com's terms of service and privacy policy. Vitamin B12 deficiency can also be found in people with poor nutrition, infection, cancer, anemia, stomach/intestinal problems and/or nerve damage. Abdominal pain is found among people who take Vitamin b12, especially for people who are female, 60+ old, have been taking the drug for < 1 month. "im b12 deficiency i'm getting injections ... would trinfac-b help.my stomach wont absorb b12. Modern Nutrition in Health and Disease, 9th ed. Consult with your physician regarding the use of acetaminophen or ibuprofen for the relief of occasional back or muscle pain from B-12 supplementation. 2008; 168:1174-80. Start now, it's free and anonymous. If you take prenatal multivitamins, strictly avoid taking more vitamins than your doctor recommends 2. Before taking this injection it was 9.8. The more common side effects include: * Mild diarrhea * Upset stomach * Nausea * A feeling of pain and a warm sensation at the site of the injection * A feeling, or a sense, of being swollen over the entire body * Headache * Joint pain If any of these side effects become severe or troublesome, let your doctor know right away. Some vitamins are best taken after a meal, while it's best to take others on an empty stomach. Common drugs people take besides Vitamin b12 *: Common side effects people have besides Abdominal pain *: Check whether Abdominal pain is caused by a drug or a condition. Patient Guide to Vitamin D Deficiency. Vitamin D: Dietary Supplement Fact Sheet. 2013;32(3):375-381. doi:10.1016/j.clnu.2012.08.014, Marcinowska-Suchowierska E, Kupisz-Urbańska M, Łukaszkiewicz J, Płudowski P, Jones G. Vitamin D Toxicity-A Clinical Perspective. Nausea (feeling of having an urge to vomit): 597 people, 30.98%, Headache (pain in head): 370 people, 19.20%, Malaise (a feeling of general discomfort or uneasiness): 239 people, 12.40%, Abdominal Distension: 238 people, 12.35%, Breathing Difficulty: 237 people, 12.30%, Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 223 people, 11.57%, Insomnia (sleeplessness): 196 people, 10.17%, Crohn's Disease (condition that causes inflammation of the gastrointestinal tract): 181 people, 9.39%, Nasopharyngitis (inflammation of the nasopharynx): 176 people, 9.13%, Urinary Tract Infection: 144 people, 7.47%, Muscle Aches (muscle pain): 135 people, 7.01%, Hypotension (abnormally low blood pressure): 135 people, 7.01%, Hypoaesthesia (reduced sense of touch or sensation): 129 people, 6.69%, Muscle Spasms (muscle contraction): 127 people, 6.59%, Musculoskeletal Stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves): 125 people, 6.49%, Haemoglobin Decreased: 117 people, 6.07%, Flatulence (flatus expelled through the anus): 115 people, 5.97%, Dehydration (dryness resulting from the removal of water): 105 people, 5.45%, Intestinal Obstruction: 104 people, 5.40%, Anaemia (lack of blood): 103 people, 5.35%, Haematochezia (passage of stools containing blood): 103 people, 5.35%, Crohn's Disease (condition that causes inflammation of the gastrointestinal tract): 527 people, 27.35%, Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 134 people, 6.95%, Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 133 people, 6.90%, Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. generic drugs) are not considered. // Leaf Group Lifestyle, Negative Side Effects of Taking Vitamin D Supplements, The Side Effects on the Stomach of Calcium & Vitamin D, Side Effects of Taking a Vitamin D and Calcium Supplement, MayoClinic.com: Vitamin B12 (Nasal Route, Oral Route, Parenteral Route): Side Effects, Holick MF, Gordon CM. Baltimore: Williams and Wilkins, 1999. You may develop a skin rash that may or may not itch while taking vitamin B-12. Other drugs that have the same active ingredients (e.g. If you want to take a step further, brew a tea of cumin seeds and drink it before bed every night and increase your consumption of things like eggs and liver. These are the five 'peculiar' signs of a B12 deficiency you should be aware of. These side effects may lessen over time as your body adjusts to B-12 supplementation. Taksler GB, Cutler DM, Giovannucci E, Keating NL. 2009; 169:384-90. Since the liver does store extra vitamin B12, and the body has a recycling process for B12, it may take an adult 3-10 years to develop a deficiency once intake of the nutrient has ceased. These may include redness, swelling, bruising or pain at the site of injection. Aug 2007: 07-E013. Impact of vitamin D supplementation during a resistance training intervention on body composition, muscle function, and glucose tolerance in overweight and obese adults. Vitamin B-12 may cause you gastrointestinal discomfort. Ginde AA, Mansbach JM, Camargo CA, Jr. Association Between Serum 25-Hydroxyvitamin D Level and Upper Respiratory Tract Infection in the Third National Health and Nutrition Examination Survey. Applies to cyanocobalamin: intramuscular solutionOther dosage forms: 1. nasal sprayAlong with its needed effects, cyanocobalamin (the active ingredient contained in Vitamin B12) may cause some unwanted effects. Am J Clin Nutr. A 12-week double-blind randomized clinical trial of vitamin D₃ supplementation on body fat mass in healthy overweight and obese women. Although not all of these side effects may occur, if they do occur they may need medical attention.Check with your doctor or nurse immediately if any of the following side effects occur while taking cyanocobalamin: B12 [vitamin b12 (liver-stomach concentrate with intrinsic factor)] is an anti-anemia preparation used to treat anemias that respond to oral hematinics, including pernicious anemia and other megaloblastic anemia and also iron-deficiency anemia.B12 is available in generic form. Infections may also occur. Clin Nutr. VITAMIN B12 deficiency symptoms can be difficult to spot, and may develop very slowly over a long period of time. Dizziness may be experienced if you take vitamin B-12. Vitamin b12 has active ingredients of cobalamin. © 2021 eHealthMe.com. SarahGen January 3, 2014 . Vitamin B12 has benefits, but as it is with all things, too much of it can be dangerous. 2011;96(7):1-2. doi:10.1210/jcem.96.7.zeg33a, Sunyecz JA. Abdominal pain is found to be related to 3,908 drugs and 4,186 conditions by eHealthMe. The study is created by eHealthMe based on reports of 73,652 people who have side effects when taking Vitamin b12 from the … Arch Intern Med. Those with B12 deficiency, ... None were taking supplements. The phase IV clinical study is created by eHealthMe based on reports of 73,652 people who have side effects when taking Vitamin b12 from the FDA, and is updated regularly. You may obtain vitamin B-12 in pill form, in a nasal solution or as an intramuscular injection. 2010;91(5):1255-1260. doi:10.3945/ajcn.2009.29094, Salehpour A, Hosseinpanah F, Shidfar F, et al. Front Endocrinol. “Taking vitamins on an empty stomach can frequently upset the GI tract,” says gastroenterologist Christine Lee, MD. The author of the study, Dr. Rosa Caballero, said that “the allergens involved in vitamin B12 reactions is likely to be a hapten .” Dosage of drugs is not considered in the study. Related publications that referenced our studies, "A case report from Nepalese community pharmacy on levofloxacin induced severe abdominal pain", Abdominal pain and drugs with ingredients of cobalamin. 2013 Jun;32(3):375-81. doi: 10.1016/j.clnu.2012.08.014. Giovannucci E, Liu Y, Hollis BW, Rimm EB. According to one study in 17 people, taking vitamin D with the largest meal of the day increased vitamin D blood levels by about 50% after just 2–3 months ( 7 ). Your diet often supplies the B vitamins you need, but in some cases, you may need a supplement to get sufficient amounts of the vitamins. Stomach bloating? I thought I was the only one who would get these terrible stomach aches after taking my Centrum Silver without Iron, I tried taking it with my meal, after my meal and before my meal and my stomach hurts a few minutes after I take it, so I stopped and feel much better without the horrible bloating and pain, I found Alive multivitamins on Amazon, they are more powerful than Centrum and … If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date. Movies, work, etc. Carrillo AE1, Flynn MG, Pinkston C, Markofski MM, Jiang Y, Donkin SS, Teegarden D. Impact of Vitamin D Supplementation During a Resistance Training Intervention on Body Composition, Muscle Function, and Glucose Tolerance in Overweight and Obese Adults. Epidemic Influenza and Vitamin D. Epidemiol Infect. Arch Intern Med. If one’s past vitamin B12 intake has been very low, a deficiency may manifest itself in much less than 3 years after cessation of intake. Vitamin B12 are easily available over-the-counter drugs and moreover most of the common non vegetarian goods we consume on a daily basis have copious amounts of it. Running one of the largest drug safety studies in the world, eHealthMe is able to enable everyone to run personal clinical trial. University of Ottawa Evidence-based Practice Center. Vitamin B12 is an important water-soluble vitamin, and deficiency is common. WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health. Abdominal pain is found among people who take Vitamin b12, especially for people who are female, 60+ old, have been taking the drug for < 1 month. It is administered either intramuscularly or subcutaneously. I have to lie on the floor no matter where I am. Will you have Oesophageal Mass with Vfend? These side effects may lessen over time as your body adjusts to B-12 supplementation. Rotate the site of injection with each administration. Epub 2010 Mar 10. Generalized pain, including arthritis, back pain and muscle pain may occur after a vitamin B12 injection. You may experience upset stomach, nausea, vomiting and diarrhea, according to Drugs.com. Check your B12. 2008;168(11):1174-1180. doi:10.1001/archinte.168.11.1174, Gorham ED, Garland CF, Garland FC, et al. it causes swelling, ulcerations, and loss of function of the large intestine): 83 people, 4.31%, Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 73 people, 3.79%, Insomnia (sleeplessness): 58 people, 3.01%, Multiple Myeloma (cancer of the plasma cells): 55 people, 2.85%, Muscle Spasms (muscle contraction): 49 people, 2.54%, Osteoporosis (bones weak and more likely to break): 43 people, 2.23%, Arthritis (form of joint disorder that involves inflammation of one or more joints): 40 people, 2.08%, Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 38 people, 1.97%, Anaemia (lack of blood): 36 people, 1.87%, Primary Myelofibrosis (primary disorder of the bone marrow): 34 people, 1.76%, Psoriasis (immune-mediated disease that affects the skin): 32 people, 1.66%, Idiopathic Pulmonary Fibrosis (chronic lung disease): 29 people, 1.50%, Neuropathy Peripheral (surface nerve damage): 28 people, 1.45%, Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 26 people, 1.35%, Headache (pain in head): 26 people, 1.35%, Paroxysmal Nocturnal Haemoglobinuria (haemoglobin in the urine): 26 people, 1.35%, Rickets (softening of bones): 25 people, 1.30%, Ankylosing Spondylitis (type of arthritis affecting the spine): 23 people, 1.19%, Seasonal Allergy (allergic condition due to certain season): 22 people, 1.14%, Hyperlipidaemia (presence of excess lipids in the blood): 21 people, 1.09%, Renal Cell Carcinoma (a kidney cancer): 21 people, 1.09%, Fibromyalgia (a long-term condition which causes pain all over the body): 21 people, 1.09%, Endometriosis (appearance of endometrial tissue outside the uterus and causing pelvic pain): 20 people, 1.04%, Polycythaemia Vera (blood disorder in which the bone marrow makes too many red blood cells): 20 people, 1.04%. 2018;9:550. doi:10.3389/fendo.2018.00550, Ross AC, Manson JE, Abrams SA, et al. It is recommended that patients use the information presented as a part of a broader decision-making process. Optimal Vitamin D Status for Colorectal Cancer Prevention: a Quantitative Meta-analysis. An abnormal increase in red blood cells, a runny nose, chest pain, a swollen tongue and fever are additional adverse reactions that may occur after the injection. 2013;24(2):567-580. doi:10.1007/s00198-012-2224-2, Urashima M, Segawa T, Okazaki M, Kurihara M, Wada Y, Ida H. Randomized trial of vitamin D supplementation to prevent seasonal influenza A in schoolchildren. Answered by Dr. Gurmukh Singh: Yes: Vitamin B 12 is a special issue. 73,652 people reported to have side effects when taking Vitamin b12. The most obvious mistake you might be making – and probably the easiest to fix – is taking them first thing in the morning before you’ve eaten. 2012;11:78. doi:10.1186/1475-2891-11-78, Carrillo AE, Flynn MG, Pinkston C, et al. Some reports may have incomplete information. All rights reserved. Dizziness should subside as your body gets used to taking additional B-12. Vitamin B-12 is a water-soluble vitamin that must be supplied daily from either food or supplementation. These vitamins are essential for numerous physiologic functions, including growth and development. Consult your physician if severe gastrointestinal discomfort occurs. Epub 2012 Aug 31. Position Statement of Vitamin D. 2010. Consult your physician regarding the use of an over-the-counter cream containing cortisone to relieve such symptoms. 2013;98(8):E1283-E1304. 25-hydroxyvitamin D and risk of myocardial infarction in men: a prospective study. Taking this vitamin with food may help alleviate gastrointestinal distress. If you are receiving vitamin B-12 via intramuscular injection, you may develop injection-site complications. It's embarrassing but The pain is unbearable. J Clin Endocrinol Metab. 2007 Mar;32(3):210-6. Am J Clin Nutr. Am J Prev Med. Back and muscle pain may occur. Here’s a case of two female Pernicious Anemia patients who had negative reactions to hydroxy B12 shots. Laura Candelaria is a family nurse practitioner and assistant professor of nursing and nutritional science. Her experience includes neonatal and pediatric intensive-care, women's oncology, gynecology, obstetrics, lactation, nutrition and infertility. Among them, 1,927 people (2.62%) have Abdominal pain. 2010 91:1255-60. i take centrum for all other vitamins will they work?" 2015;18(3):379-391. doi:10.1017/S1368980014000457, Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. The phase IV trial will monitor drug safety outcomes that are personalized to your gender and age (0-99+). The use of the eHealthMe site and its content is at your own risk. My girls says I'm over reacting, she says, "It's just a vitamin." The use of calcium and vitamin D in the management of osteoporosis. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. But I am reading over the internet that it could ... Read More. Different individuals may respond to medication in different ways. Taking acetaminophen under the direction of a physician may lessen these effects. Vitamin B-12 is essential to proper red blood cell functioning, because the vitamin helps produce hemoglobin -- the compound your red blood cells require to carry oxygen. You should use caution while driving or completing tasks that may be dangerous if you experience such an effect. * Approximation only. American Academy of Dermatology. I've notice that every time I start to use a vitamin, my stomach feels like someone is stabbing me. In one case study, a boy developed stomach pain after taking improperly labeled vitamin D supplements, whereas his brother experienced elevated …