It is also used for preventing disorders of the heart and blood vessels, including stroke, heart disease, and varicose veins. Blood pressure. Essentially, yes. [Source 49)] Pycnogenol and ADHD. Clin Interv Aging. No side effects were noted.75, The journal Phytotherapy Research reported a clinical study with Japanese patients with mild-to-moderate ED to determine the efficacy of a supplement regimen of Pycnogenol (60 mg/day), l-arginine (690 mg/day), and aspartic acid (552 mg/day). Pycnogenol. Life Sci. Pycnogenol, taken as a supplement in pill form, is 50 times more powerful than Vitamin E as an antioxidant. Pycnogenol is the trade name for an extract of French maritime pine bark (Pinus pinaster). Is a product labeled "pine bark extract" the same as Pycnogenol? Pycnogenol is a patented blend of bioflavonoids that are derived from pine bark. Helps Lung Disease. Pycnogenol® ist ein natürlicher Pflanzenextrakt aus der Rinde der französischen Meereskiefer, die entlang der südwestlichen Küste Frankreichs wächst. Effects of the antioxidant Pycnogenol on cellular redox systems in U1285 human lung carcinoma cells Valentina Gandin1,*, Christina Nystro¨m1, Anna-Klara Rundlo¨f1, Kerstin Jo¨nsson-Videsa¨ter2, Frank Scho¨nlau3, Jarmo Ho¨rkko¨4, Mikael Bjo¨rnstedt1 and Aristi P. Fernandes1 1 Division of Pathology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska … Pycnogenol has been found to be useful in relieving symptoms in postmenopausal women. The leuprorelin group had a greater response within the treatment period but relapsed after 24 weeks posttreatment. In a study published in the Journal of Sexual and Marital Therapy, the investigators reported testing the possibility of overcoming ED by increasing the amounts of endogenous NO. By continuing you agree to the use of cookies. It is a highly contagious respiratory disease that attacks the nose, throat, and lungs, and can even send a person to the hospital. Study results showed that the participants' blood pressure, C-reactive protein (a marker of inflammation), blood sugar, and cholesterol levels remained essentially the same in both groups throughout the study.. Summary. 2014;105(3):245-54. Pycnogenol has been proven effective against asthma, erectile dysfunction, retinopathy, diabetes and arthritis, among others. Pycnogenol may increase levels of antioxidant enzymes and decrease levels of nitrogen species, suggesting that antioxidants minimize the effects of acute ozone exposure via a … Pycnogenol is a proprietary antioxidant–bioflavonoid mixed extract isolated from the bark of the maritime pine (Pinus pinaster). Mega Antioxidant is a combination of Pycnogenol with other potent antioxidants like Astaxanthin, Lutein, Lycopene, Green Tea … How and Where to Buy Pycnogenol. 32.3. After three months, about 45% of those who took Pycnogenol were completely asymptomatic compared to 23% of controls.. Some researchers reported that oxidative stress may underlie symptoms of Parkinson’s disorder (Olanow, 1996), and some have hypothesized that similar factors may underlie symptoms of ADHD. The antioxidant effects of Pycnogenol are fur- ther supported by our finding that Pycnogenol decreases the production of hydrogen peroxide when added in combination with compounds known to pro- duce ROS, including selenite (Fig. Download Full PDF Package. They proposed oral administration of Pycnogenol because it promotes increased production of NO by NOS together with l-arginine. Adults taking pycnogenol have been reported to have significantly reduced serum leukotrienes. Normalizing blood vessel diameter naturally helps maintain blood pressure that is already in the normal range. Attention-deficit and hyperactivity disorder (ADHD) is a complex and multifactorial disorder, influenced by both genetics and the environment. Pine Bark Extract. Now Foods - Pycnogenol 30mg - 30 veg caps: Amazon.nl Selecteer uw cookievoorkeuren We gebruiken cookies en vergelijkbare tools om uw winkelervaring te verbeteren, onze services aan te bieden, te begrijpen hoe klanten onze services gebruiken zodat we verbeteringen kunnen aanbrengen, en om advertenties weer te geven. Pycnogenol is a substance taken from the pine bark of trees found in the southwest region of France. Improved Muscle and Tissue Performance. Recent studies have also shown that supplementation may help to limit symptoms associated with chronic inflammation in autoimmune disease. Procyanidins are chain-like structures consisting of catechins, which confer the supplement's antioxidant properties. Furumura M, Sato N, Kusaba N, Takagaki K, Nakayama J. The manufacturer recommends 1 mg/kg/day. Furumura M, Sato N, Kusaba N, Takagaki K, Nakayama J. Aljun Guilaran. These bioflavonoids hook up with vitamin C and help to boost immune function. 30.2). For pine bark, it is best to standardize in the 65 – 75% active ingredient range, which is the pycnogenol exact. Bereits ab 19,45 € Große Shopvielfalt Testberichte & Meinungen | Jetzt Pharma Nord Pycnogenol Kiefernrindenextrakt Dragees (60 Stk.) [1] Pycnogenol kommt dabei vermutlich die Funktion zu, dass es die Entstehung von Stickstoff in den Zellen der Gefäßinnenwände fördert. Randy J. Horwitz MD, PhD, in Integrative Medicine (Fourth Edition), 2018. The study involved 130 overweight people, all of whom had elevated blood pressure but weren't taking blood pressure medication. In terms of allergic diseases, it has been shown to be efficacious in a murine model of airway inflammation,26 as well as in a clinical trial of children with asthma.27 In this study, Pycnogenol improved asthma symptoms and pulmonary function and decreased rescue inhaler use. The active ingredients in pycnogenol can also be extracted from other sources, including peanut skin, grape seed, and witch hazel bark.. Pycnogenol is used for treating circulation problems, allergies, asthma, ringing in the ears, high blood pressure, muscle … Pycnogenol is often touted as a remedy for high blood pressure, inflammation, and other problems known to increase the risk of heart disease; again here, its effects on the functioning of the endothelium are believed to be at play. The recommended dose used in asthma studies is 1 mg/lb body weight in two divided doses. However, because it may produce vasorelaxation and inhibition of platelet activity, those who take blood thinners (for example, aspirin) should exercise caution. Pycnogenol, as a patented formulation of French maritime pine bark extract, is standardized to 65% to 75% procyanidin compounds by weight. Pycnogenol is generally dosed at the ratio of 1 mg/kg, and adult doses range from 25–200 mg/day. Pycnogenol’s antioxidant activities can be increased by Ginkgo Biloba (EGb 761). At six months, 87% of those who took Pycnogenol were asymptomatic, compared to almost 35 percent of controls, and had significantly better blood flow in the cochlea (a part of the inner ear that plays a key role in hearing). Pycnogenol® has been used in adult patients with ADHD to improve concentration, ... lung cancer, musculoskeletal problems, osteoporosis, periodontitis, poor tissue healing, premenstrual syndrome, macular degeneration, motion sickness, myocardial ischemia/reperfusion injury, myalgia, myopathy, night vision, pelvic pain, neurodegenerative diseases, prevention of fat … (formerly known as Pinus maritime Mill.). Phytother Res. Pycnogenol can be taken for treating circulation problems, allergies, asthma, ringing in the ears, high blood pressure, muscle soreness, pain, osteoarthritis, diabetes, attention deficit hyperactivity disorder (ADHD), a disease of the female reproductive system called endometriosis, menopausal symptoms, painful menstrual periods, erectile dysfunction, and an eye disease called retinopathy. Three months after PYC administration, the level of total cholesterol decreased significantly, as did also LDL-C. Notably, the treatment effects were more significant in boys than in girls. Her work is regularly featured in media such as First For Women, Woman's World, and Natural Health. Some people taking pycnogenol may experience bad breath, upset stomach, dizziness, sores in the mouth, or headaches. 2006;12(2):205-12. doi:10.1177/107602960601200209, Stanislavov R, Nikolova V. Treatment of erectile dysfunction with pycnogenol and L-arginine. $24.05 $ 24. For the elderly or very young, the flu can be life-threatening. One study published in 2010 tested this using a combination of Pycnogenol and other ingredients (most commonly L-arginine). Pycnogenol® in Chronic Venous Insufficiency and Related Venous Disorders. Es enthält Polyphenole und wird u. a. in Nahrungsergänzungsmitteln und in Kosmetika eingesetzt. In … Its exact pathophysiology remains, however, unclear. During the second month, patients were additionally supplemented with 40 mg Pycnogenol two times per day; during the third month, the daily dosage was increased to three 40 mg Pycnogenol tablets. 2012;25(2):86-92. doi:10.1159/000335261, Ⓒ 2021 About, Inc. (Dotdash) — All rights reserved, Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Arthritis: The dose used in clinical trials was 100-150 mg/day. A leading cause of blindness among people with diabetes, diabetic retinopathy occurs when leaky blood vessels damage the retina (a light-sensitive layer of tissue at the back of the inner eye). Although Pycnogenol is generally considered safe, it may interfere with the action of certain drugs used in chemotherapy and radiation therapy. Pine bark may help combat progression of Chronic Obstructive Pulmonary Disorder (COPD). Treatment with Pycnogenol was well tolerated.114. After confirming regular menstruation and ovulation for 3 months, they were randomized to receive either Pycnogenol 30 mg twice daily for 48 weeks or a GNRH agonist, leuprorelin acetate depot, 3.75 mg intramuscularly (IM) every 4 weeks for 24 weeks. R Find similar products. E. Sieniawska, T. Baj, in Pharmacognosy, 2017. Furthermore, a significant increase of plasma antioxidant activity was observed. Minerva Med. Read … Pycnogenol is the registered trademark name for a French formula. Clin Appl Thromb Hemost. Pycnogenol is the registered trademark name for a French formula. Pine bark may help combat progression of Chronic Obstructive Pulmonary Disorder (COPD). R. 17. However, according to a larger study published in JAMA Internal Medicine in 2010, French maritime pine bark extract may not enhance heart health for the general population. * A double-blind trial using Pycnogenol at a dosage of 100 mg per day showed Pycnogenol to reduce pain and other osteoarthritis symptoms. Five of the women taking Pycnogenol became pregnant.108, George M. Kapalka, in Nutritional and Herbal Therapies for Children and Adolescents, 2010. Helps Lung Disease. Naturally, the percentage is lower in asthmatics as their airways are constricted, and … Pycnogenol can be added to existing allergy/asthma regimens. Summary: These studies demonstrate that Pycnogenol treatment alleviates OA symptoms and is effective in reducing NSAID or COX-2 inhibitor medication over 3 months, suggesting that Pycnogenol could be used as an effective adjuvant treatment for OA symptoms. Arch Intern Med. 3). Yuan Z. Lim, ... Yuanyuan Wang, in Bioactive Food as Dietary Interventions for Arthritis and Related Inflammatory Diseases (Second Edition), 2019. Pycnogenol is supplied in 30-, 50-, and 100-mg tablets. In a study published in 2008, people with diabetes and early-stage retinopathy took Pycnogenol or a placebo daily for three months. Blood pressure declined, and there was a slight increase in salivary testosterone in the supplement group as compared to controls. 2001;24(3):161-171. doi:10.1023/a:1021160924583. Nach einer gründlichen Reinigung wird der Rohextrakt sprühgetrocknet und zu einem feinen, braunen Pulver verarbeitet. 2012;7:275-86. doi: 10.2147/CIA.S33165. John D. Mark MD, in Integrative Medicine (Fourth Edition), 2018, Pycnogenol (a proprietary mixture of water-soluble bioflavonoids extracted from French maritime pine) has been used for its antiinflammatory properties in conditions such as asthma. ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. Monomeric catechin, free taxifolin and its glucoside, as well as vanillin are also present. Pycnogenol is derived from the bark of the Maritime pine from Gascony in southwest France, which is rich in procyanidins, bioflavonoids and organic acids. Memorial Sloan Kettering Cancer Center. A Summary of Pycnogenol’s Benefits. Pycnogenol is generally supplied in tablets and capsules, and creams and lotions containing it are also available but have not been studied for their effectiveness. Study results showed that 18 of the 24 participants who took Pycnogenol had an improvement in their vision, while no such improvements were observed in those who took the placebo. PPTX. Pycnogenol has a variety of biological activities, ranging from blood pressure reduction to mitigation of elevated blood glucose. When you sit still for long periods of time (for example, on a long airplane flight), you are at risk for developing dangerous blood clots in your legs. Pycnogenol by Health Origins has no other ingredients aside from Pycnogenol, offering a concentrated dose of this antioxidant. Pycnogenol is the US registered trademark name for a product derived from the pine bark of a tree known as Pinus pinaster. In laboratory research, Pycnogenol was found to selectively inhibit matrix metalloproteinases and inflammatory cells and inhibit cyclooxygenases 1 and 2. Free PDF. Pycnogenol increases collagen and hyaluronic acid production, two components of popular anti-aging products that may lead to more hydrated and elastic skin. It is a natural source of several antioxidants including proanthocyanidins, which are also found in wine, grapes, apples, cocoa, tea, nuts, and some berries. Read our, Medically reviewed by Lana Butner, ND, LAc, Medically reviewed by Arno Kroner, DAOM, LAc, Medically reviewed by Rochelle Collins, DO, Medically reviewed by Richard N. Fogoros, MD, Verywell Health uses cookies to provide you with a great user experience. Its quality is specified in the United States Pharmacopeia . Pycnogenol also inhibits the enzymes responsible for the destruction of lung tissue in chronic bronchitis. This preparation is thought to exert its effect by blocking leukotrienes and other cytokines that increase inflammation and cause asthma symptoms. Replied by Art (California) 11/04/2017 799 posts. A study conducted in children with mild-to-moderate asthma using the supplement for 3 months showed significantly more improvement in pulmonary functions and asthma symptoms and found that they could reduce their use of prescription medication. Copyright © 2021 Elsevier B.V. or its licensors or contributors. In a double-blind, placebo-controlled study of patients with knee OA over 3 months, the Pycnogenol arm had greater improvement in the global WOMAC score and walking distance in the treadmill test, reduced NSAID use, and decreased gastrointestinal complications and foot edema.112 Similar findings were observed in a 3-month randomized, double-blind, parallel-group, placebo-controlled trial of knee OA patients, showing significant improvement in WOMAC pain, physical function and total scores, and reduced dosage and frequency of NSAIDs or selective COX-2 inhibitors in the Pycnogenol group compared with the placebo group.113 In another randomized, double-blind, placebo-controlled trial of patients with mild to moderate knee OA over 3 months, the Pycnogenol group reported significant improvement in WOMAC index and VAS pain and reduction in NSAID use compared with the placebo arm.