If a positive ANA result is felt to be unrelated to an active rheumatic diagnosis but there remains a risk for development of rheumatic disease, the patient may be monitored. Having a positive ANA with a speckled pattern does not necessarily mean one has an AI. Otherwise, monitoring is not indicated for an isolated positive ANA. The results of my ANA test is 1:160 titer speckled pattern. Check to see if the pattern associated with the titer is homogenous (diffuse). Check to see if the pattern reported is speckled. The apparent great difference between various titers can be misleading. The incidence and titers in these individuals increase with age. 5% of the population will have a titer positive at 1:160 3% of the population will have a titer positive at 1:320 A titer of 1:160 or above is commonly considered a positive test result. The titer indicates how many times the lab technician had to dilute plasma from the blood to get a sample free of the antinuclear antibodies. The ANA test is very sensitive to picking up anti-nuclear antibodies. Comment from: Curious, 45-54 Female (Patient) Published: May 29 I had a positive ANA screen show up on my blood work with a 1:1280 titer with a nuclear pattern. A speckled pattern in an anti-nuclear antibodies test may indicate Sjogren syndrome, scleroderma, polymyositis, rheumatoid arthritis or mixed connective tissue disease, according to Lab Tests Online. Another pattern, known as a nucleolar pattern, is common in people with scleroderma. Clinical features in the context of supportive bloodwork/imaging helps physicians determine whether one has an AI or is at risk of having an AI. A speckled pattern is also found in lupus. "what does a positive ana 1:160 with speckled pattern mean?" A positive ANA test is usually reported as both a ratio (called a titer) and a pattern, such as smooth or speckled. This ANA pattern tends to be associated with specific antibodies as opposed to a homogenous pattern ANAs. For example, a titer of 1:640 shows a greater concentration of anti-nuclear antibodies than a titer of 1:320 or 1:160. This pattern can indicate a diagnosis of systemic lupus erythematosus or mixed connective tissue disease. A positive ANA test means that you have high levels of ANA in your blood. Similarly, a speckled pattern on the ANA test can indicate almost ANY autoimmune disease, this is because a speckled pattern like a 1:80 titer level is not very significant. Low Titer (1:40) Speckled Pattern Sera from some individuals with no apparent connective tissue disease have low titered speckled ANA's. A speckled pattern may also appear on tests of individuals with systemic lupus, states the Johns Hopkins Lupus Center. In a group of 100 randomly selected people, about 30 would have an ANA positive test at the 1:40 titre, about 10 would be positive at the 1:80 titre, and 3 would be positive at a 1:160 titre. A titer of 1:160 or above is commonly considered a positive test result.
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